(There's a note in the instructions regarding hardware-accelerated rendering for those interested.) The downside of this approach is that the game still uses software rendering however, I think this is an acceptable tradeoff for getting it in a playable state quickly and keeping the process simple. Using DxWnd alone gets the game running at an appropriate frame rate without requiring any changes to the game files or risking the introduction of new bugs. Running Interstate '76 at a reduced frame rate resolves a number of bugs, including the player's vehicle being unable to make jumps and computer-controlled vehicles driving slowly while rapidly steering left and right. Working through them should take five minutes or less.
These instructions are intended to be clear and concise. CahootsMalone/interstate-76-stuff/blob/master/running-interstate-76-gog-release-using-dxwnd.md I've written instructions that explain how to run the GOG release of Interstate '76 at a reduced frame rate using DxWnd (avoiding the timing-related bugs that affect the GOG release as-is):